I think Peter D’s theories are the saturated fat affects the brain too (via the fat cells), and I think it’s via the hypothalamus. However, his site seems to be blank now, so I can’t search it.
Peeing a bunch on keto on day 12 n 13 am I getting too much protein?
Leptin is supposed to be the mediator of that. I don’t think it’s limited to saturated fats either; my understanding is that it’s the aggregation of triglycerides inside the cell that triggers the leptin secretion.
Of course, Peter is very sharp, so there may be something I’ve missed, here.
I remember reading how he thought the insulin resistance in fat cells caused by saturated fat related to effects in the brain. Unfortunately, his site appears to be basically gone. No articles.
I never paid that much attention to that part of his theory, and now I can’t remember what it was.
I also have concerns that his theory works well – in mice; in humans, I’m not sure how well it works. We might be too complex.
Ideally, the body knows what it wants… But it’s not ideal for many of us (especially not in the beginning I imagine). Exactly what and when we eat can have a huge impact on food intake anyway, I have that.
Some people has weird or lacking signals. Like no hunger or no satiation ever. Maybe appetite is off too and they just starve without noticing it.
I am against force unless we need it because we are starving without it. I still would try to figure out HOW to eat enough without force (or quit keto. I have read about someone once who rapidly lost weight even while underweight as they just couldn’t eat not little on keto. they used it for fat-loss only as it always happened and they couldn’t even maintain or gain on it. weird but some people get this low appetite/hunger and easy/long-term satiation, it seems).
So if you starve (even if you eat good food but way too little), you should eat more somehow, hunger or no hunger. The occasional low-cal or fasting day is fine and dandy but several days in row without proper nutrition causes problems, at least a slowed down metabolism for a while.
That’s normal I guess. I have weeks without hunger (I eat properly, I guess hunger or some other urge would come with vengence if I just wouldn’t ;)).
(And my hunger has little to no correlation with my appetite but that’s another thing. I still find it interesting that it’s the same/closely correlated for many people. My need for food is the third thing, again, not very well correlated with the previous ones. That’s why I eat normally with zero hunger, I get other urges or warnings. I consider “need for fuel” the most important one, I only care about hunger if it bothers me. Some soft hunger with the feeling I have plenty of energy and zero desire to eat results in no eating. Zero hunger and appetite with serious warning signs about my body losing its patience results in eating, no matter what, I find a way (I wrote about my gateway items before). I don’t argue with my body in that state. I get weak and dizzy or can’t concentrate? Time to eat. That’s what I do when I have my no hunger times. My body NEEDS the food. And I feel not quite right until it gets it.)
But if one is very fine with very little food for longer term, it’s still a problem. It’s not right. No idea why the body doesn’t nudge the host/mind but some don’t do that. But the negative effects will come eventually.
I would agree it’s not just the saturated fats, but the aggregate of the triglycerides. Similar to insulin resistance, if we are overfat and constantly secreting leptin, our brains become leptin resistant.
Patience is necessary in the journey and consistency is critical. Continue to monitor your carbs and make sure you are staying under your threshold. Then, prioritize protein and fill in the rest with fat. Our bodies break down and metabolize stored body fat at a given rate, so we need exogenous energy to ensure our bodies don’t think a famine is occurring.
Healing will take time and persistent adherence to control of carbs. Once you bring that insulin down and excess in your systems starts to normalize, you can better rely on signals and cues from your body.
My understanding is that “leptin-resistance” is a misnomer; what is really going on is that the elevated insulin from excessive dietary carbohydrate blocks the leptin receptors, not that the brain down-regulates them. So to my mind, the proper term would be “leptin-blocking.” Once we lower carb intake low enough for serum insulin to drop, the brain seems to register leptin quite easily. By contrast, insulin-resistance results when cells actually down-regulate the number of insulin receptors on their surface. The ventromedial hypothalamus is not down-regulating its leptin receptors; they are being interfered with.
If you think about it, this makes sense, because leptin-blocking is basically the mechanism by which animals prepare for hibernation. We don’t want leptin sensitivity to be down-regulated, just blocked long enough for us to put on weight for the winter.
HIGHLY unlikely you’re eating too much protein, aside from that not really being a thing, Cronometer gives you real low limits most of the time. What are your stats and how much are you eating?
You don’t, that’s keto screwup #1, Ketosis is from lack of carbs, not from high fat. There’s no rule or need to eat tons of fat, only enough for fuel and hormones. Figure out all your protein needs, get in the carbs you’re going to eat, fat can fill in the blanks… or fill them until it’s enough and you could take in more protein. Really depends on how you eat.
I agree the leptin is being blocked, and me referring to it as leptin resistance was just perpetuating the colloquialism, which is a misnomer.
So as long as insulin is sufficiently low, the hypothalamus will most likely register leptin levels accurately?