By what process? If your insulin is low enough to release stored fat for fuel on top of the fact we know this is an on demand system why would we release “extra” for lack of a better term, and with that insulin low what would tell the fat to re-store in fat cells, without the insulin that makes no sense. First I’ve ever heard this. Please provide links to something about this, I can’t find anything on it.
Do spare ketones in blood revert back to fat?
J_A-M
(Jay AM)
#23
I think of it more like a super computer run machine. Machines break and malfunction, especially with the wrong inputs and materials. But, they run efficiently when given the proper programming, tools, inputs, materials.
The machine’s goal is to run the factory. The computer controls the machine. We manage the warehouse.
What I find interesting is survival mechanisms that come about in different situations where the body preserves life at the expense of sentience. I feel like there’s an algorithmic goal here somewhere in the wiring when this happens but it’s such a unique event.
/ramble
Jason_v
#24
nothing in physiology is on/off, start/stop etc. its all about up regulation and down regulation, and there are many integrative layers.
ketones are a by product of fat metabolism in the liver. when you are metabolizing fat for energy (which happens in the absence of exogenous carbohydrate or a prolonged reduction in exogenous energy in general) body fat is more liberated (fat flux is always happening to some degree, but the presence of insulin due to carbohydrates DOWN regulates lipolysis). some fat is always being liberated because its easier than completely stopping and starting it in an emergency but it is greatly minimized by the presence of easy to burn energy in the blood stream (carbs)
when fat is oxidized in the liver because of the lack of exogenous carbohydrates (or starvation or exercise or all of the above) the body starts fuel partitioning more effectively. the blood glucose is kept at a minimal, maximumly efficient level for the tissues that need it (some renal cells, red blood cells, a large % of brain cells) the muscles take up the fat, and the ketone byproducts are shunted to the tissues that can most readily use them (current thinking is the brain and heart and other nervous system related cells)
there is never a moment when all the tissues aren’t taking up energy, so in the absence of free easy to burn glucose, the presence of plenty of easily mobilized fat, and ketones all tissues are happy and the ketones are free to circulates until they are taken up or encounter a different exit strategy (breath or urine). if the demand for energy increase the mechanisms by which ketones glucose etc are excreted are DOWN regulated, and the mechanism by which they are consumed is UP regulated
ketones cannot be converted back to fat to any significant degree as far as we know. some people may challenge this by consuming huge quantities of exogenous ketones at some point though.
the idea that the ketone “adaptation” is because the body starts making less of them is 100% incorrect. the body can’t make less of them as long as it is burning fat in the absence of carbohydrates. its physiologically impossible. what is more likely is the tissues get better at consuming them so at any given point you see less of them in the blood stream.
LeCheffre
(Banting & Yudkin & Atkins & Eadeses & Cordain & Taubes & Volek & Naiman & Bikman )
#26
Tubes for bacteria to control.